Article
A new class of synthetic retinoid antibiotics effective against bacterial persisters.
Nature - 5 Apr 2018
Kim Wooseong, Zhu Wenpeng, Hendricks Gabriel Lambert, Van Tyne Daria, Steele Andrew D, Keohane Colleen E, Fricke Nico, Conery Annie L, Shen Steven, Pan Wen, Lee Kiho, Rajamuthiah Rajmohan, Fuchs Beth Burgwyn, Vlahovska Petia M, Wuest William M, Gilmore Michael S, Gao Huajian, Ausubel Frederick M, Mylonakis Eleftherios
Abstract excerpt
A challenge in the treatment of Staphylococcus aureus infections is the high prevalence of methicillin-resistant S. aureus (MRSA) strains and the formation of non-growing, dormant 'persister' subpopulations that exhibit high levels of tolerance to antibiotics and have a role in chronic or recurrent infections. As conventional antibiotics are not effective in the treatment of infections caused by such bacteria,...
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