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Article

Non-antibiotic Small-Molecule Regulation of DHFR-Based Destabilizing Domains In Vivo

15 Aug 2019

Abstract excerpt

simply by administration of its stabilizing ligand, the routinely prescribed antibiotic trimethoprim (TMP). However, chronic TMP use drives development of antibiotic resistance (increasing likelihood of subsequent infections) and disrupts the gut microbiota (linked to autoimmune and neurodegenerative diseases), tempering translational excitement of this approach in model systems and for treating human diseases....

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PMID: 31649953
DOI: 10.1016/j.omtm.2019.08.002

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