Article
MicroRNA-146a Deficiency Protects against Listeria monocytogenes Infection by Modulating the Gut Microbiota.
International journal of molecular sciences - 26 Mar 2018
Du Chong-Tao, Gao Wei, Ma Ke, Yu Shui-Xing, Li Na, Yan Shi-Qing, Zhou Feng-Hua, Liu Zhen-Zhen, Chen Wei, Lei Lian-Cheng, Yang Yong-Jun, Han Wen-Yu
Abstract excerpt
The gut microbiota and microRNAs play important roles in the defense against infection. However, the role of miR-146a in L. monocytogenes infection and gut microbiota remains unclear. We tried to determine whether miR-146a controlled L. monocytogenes infection by regulating the gut microbiota. Wild-type and miR-146a-deficient mice or macrophages were used to characterize the impact of miR-146a on animal survival,...
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