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Article

A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection

1 Aug 2013

Abstract excerpt

Pathogens dramatically affect host cell transcription programs for their own profit during infection, but in most cases, the underlying mechanisms remain elusive. We found that during infection with the bacterium Listeria monocytogenes, the host deacetylase sirtuin 2 (SIRT2) translocates to the nucleus, in a manner dependent on the bacterial factor InlB. SIRT2 associates with the transcription start site of a...

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PMID: 23908241
DOI: 10.1126/science.1238858

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