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Article

Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes.

Virulence - 1 Jan 2015

Brandão Fabiana As, Derengowski Lorena S, Albuquerque Patrícia, Nicola André M, Silva-Pereira Ildinete, Poças-Fonseca Marcio J

Abstract excerpt

Cryptococcus neoformans undergoes phenotypical changes during host infection in order to promote persistence and survival. Studies have demonstrated that such adaptations require alterations in gene transcription networks by distinct mechanisms. Drugs such as the histone deacetylases inhibitors (HDACi) Sodium Butyrate (NaBut) and Trichostatin A (TSA) can alter the chromatin conformation and have been used to...

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Identifiers

PMID: 26103530
DOI: 10.1080/21505594.2015.1038014
PMCID: PMC4720250

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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