Article
Msx2 Prevents Stratified Squamous Epithelium Formation in the Enamel Organ.
Journal of dental research - 1 Nov 2018
Nakatomi M, Ida-Yonemochi H, Nakatomi C, Saito K, Kenmotsu S, Maas R L, Ohshima H
Abstract excerpt
Tooth enamel is manufactured by the inner enamel epithelium of the multilayered enamel organ. Msx2 loss-of-function mutation in a mouse model causes an abnormal accumulation of epithelial cells in the enamel organ, but the underlying mechanism by which Msx2 regulates amelogenesis is poorly understood. We therefore performed detailed histological and molecular analyses of Msx2 null mice. Msx2 null ameloblasts and...
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