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Foxp4 <sup>+</sup> Mandibular Skeletal Stem Cells Orchestrate Bone/Tooth Development and Regeneration

2026-05-01

Abstract excerpt

<h4>Summary</h4> The identity of stem/progenitor cells that drive mandible/tooth development and regeneration remains poorly understood. Here, we show that cranial neural crest-derived Foxp4 + mesenchymal cells condense to form Meckel’s cartilage, and simultaneously promote mandible development and tooth germ formation. In postnatal mandibles, Foxp4 + cells localize in the endosteum, periosteum and dental pulp,...

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Literature Corpus work
0eb48025-2ce2-5492-bca8-7f6d7f8950f1
DOI
10.64898/2026.04.29.721551
Open publication

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