Article
Cessation of Fgf10 signaling, resulting in a defective dental epithelial stem cell compartment, leads to the transition from crown to root formation.
Development (Cambridge, England) - 1 Apr 2006
Yokohama-Tamaki Tamaki, Ohshima Hayato, Fujiwara Naoki, Takada Yunosuke, Ichimori Yasuo, Wakisaka Satoshi, Ohuchi Hideyo, Harada Hidemitsu
Abstract excerpt
Mouse, rat and human molars begin to form root after the completion of crown formation. In these teeth, fibroblast growth factor (Fgf) 10 disappears in the transitional stage from crown formation to root. By contrast, rodent incisors and vole molars demonstrate continuous growth, owing to the formation and maintenance of a stem cell compartment by the constant expression of Fgf10. To clarify the relationship...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.