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Novel strategies for expansion of tooth epithelial stem cells and ameloblast generation

18 Mar 2020

Abstract excerpt

Enamel is secreted by ameloblasts derived from tooth epithelial stem cells (SCs). Humans cannot repair or regenerate enamel, due to early loss of tooth epithelial SCs. Contrarily in the mouse incisors, epithelial SCs are maintained throughout life and endlessly generate ameloblasts, and thus enamel. Here we isolated Sox2-GFP+ tooth epithelial SCs which generated highly cellular spheres following a novel in vitro...

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PMID: 32188889
DOI: 10.1038/s41598-020-60708-w

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