Article
Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis.
Cardiovascular research - 1 Jul 2018
Deutsch Marcus-André, Doppler Stefanie A, Li Xinghai, Lahm Harald, Santamaria Gianluca, Cuda Giovanni, Eichhorn Stefan, Ratschiller Thomas, Dzilic Elda, Dreßen Martina, Eckart Annekathrin, Stark Konstantin, Massberg Steffen, Bartels Anna, Rischpler Christoph, Gilsbach Ralf, Hein Lutz, Fleischmann Bernd K, Wu Sean M, Lange Rüdiger, Krane Markus
Abstract excerpt
Aims: The contribution of resident stem or progenitor cells to cardiomyocyte renewal after injury in adult mammalian hearts remains a matter of considerable debate. We evaluated a cell population in the adult mouse heart induced by myocardial infarction (MI) and characterized by an activated Nkx2.5 enhancer element that is specific for multipotent cardiac progenitor cells (CPCs) during embryonic development. We...
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