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Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration

13 Dec 2022

Abstract excerpt

Abstract The epicardium, a mesothelial cell tissue that encompasses vertebrate hearts, supports heart regeneration after injury through paracrine effects and as a source of multipotent progenitors. However, the progenitor state in the adult epicardium has yet to be defined. Through single-cell RNA-sequencing of isolated epicardial cells from uninjured and regenerating adult zebrafish hearts, we define the...

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PMID: 36513650
DOI: 10.1038/s41467-022-35433-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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