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Article

Cardiac Regeneration from Activated Epicardium

20 Sept 2012

Abstract excerpt

In contrast to lower vertebrates, the mammalian heart has a very limited regenerative capacity. Cardiomyocytes, lost after ischemia, are replaced by fibroblasts. Although the human heart is able to form new cardiomyocytes throughout its lifespan, the efficiency of this phenomenon is not enough to substitute sufficient myocardial mass after an infarction. In contrast, zebrafish hearts regenerate through epicardial...

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PMID: 23028582
DOI: 10.1371/journal.pone.0044692

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