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Article

Limited Regeneration Potential with Minimal Epicardial Progenitor Conversions in the Neonatal Mouse Heart after Injury

1 Jul 2019

Abstract excerpt

The regeneration capacity of neonatal mouse heart is controversial. In addition, whether epicardial cells provide a progenitor pool for de novo heart regeneration is incompletely defined. Following apical resection of the neonatal mouse heart, we observed limited regeneration potential. Fate-mapping of Tbx18 MerCreMer mice revealed that newly formed coronary vessels and a limited number of cardiomyocytes were...

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Identifiers

PMID: 31269439
DOI: 10.1016/j.celrep.2019.06.003

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