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Article

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions.

Aging cell - 1 Jun 2018

Dato Serena, Soerensen Mette, De Rango Francesco, Rose Giuseppina, Christensen Kaare, Christiansen Lene, Passarino Giuseppe

Abstract excerpt

In human longevity studies, single nucleotide polymorphism (SNP) analysis identified a large number of genetic variants with small effects, yet not easily replicable in different populations. New insights may come from the combined analysis of different SNPs, especially when grouped by metabolic pathway. We applied this approach to study the joint effect on longevity of SNPs belonging to three candidate pathways,...

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Identifiers

PMID: 29577582
DOI: 10.1111/acel.12755
PMCID: PMC5946073

Genes

GHSR
PTPN1
ERCC2
PAPPA
PARK7
TXNRD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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