Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

doi:10.1016/j.exger.2012.02.010

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Article

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.

Experimental gerontology - 1 May 2012

Soerensen Mette, Dato Serena, Tan Qihua, Thinggaard Mikael, Kleindorp Rabea, Beekman Marian, Jacobsen Rune, Suchiman H Eka D, de Craen Anton J M, Westendorp Rudi G J, Schreiber Stefan, Stevnsner Tinna, Bohr Vilhelm A, Slagboom P Eline, Nebel Almut, Vaupel James W, Christensen Kaare, McGue Matt, Christiansen Lene

Abstract excerpt

Here we explore association with human longevity of common genetic variation in three major candidate pathways: GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidants by investigating 1273 tagging SNPs in 148 genes composing these pathways. In a case-control study of 1089 oldest-old (age 92-93) and 736 middle-aged Danes we found 1 pro/antioxidant SNP (rs1002149 (GSR)), 5 GH/IGF-1/INS...

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Identifiers

PMID: 22406557
DOI: 10.1016/j.exger.2012.02.010
PMCID: PMC3334439

Genes

INS
RAD52
WRN
XDH
GHRHR
GHRL
GHSR
GSR
MLH1
NTHL1
POLB
XRCC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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