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Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging

23 Mar 2018

Abstract excerpt

Chronic obstructive pulmonary disease (COPD) has been recently characterized as a disease of accelerated lung aging, but the mechanism remains unclear. Tetraspanins have emerged as key players in malignancy and inflammatory diseases. Here, we found that CD9/CD81 double knockout (DKO) mice with a COPD-like phenotype progressively developed a syndrome resembling human aging, including cataracts, hair loss, and...

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PMID: 29572511
DOI: 10.1038/s41598-018-23338-x

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