Article
Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary disease-like phenotype in mice.
The Journal of biological chemistry - 19 Sept 2008
Takeda Yoshito, He Ping, Tachibana Isao, Zhou Bo, Miyado Kenji, Kaneko Hideshi, Suzuki Mayumi, Minami Seigo, Iwasaki Takeo, Goya Sho, Kijima Takashi, Kumagai Toru, Yoshida Mitsuhiro, Osaki Tadashi, Komori Toshihisa, Mekada Eisuke, Kawase Ichiro
Abstract excerpt
CD9 and CD81 are closely related tetraspanins that regulate cell motility and signaling by facilitating the organization of multimolecular membrane complexes, including integrins. We show that CD9 and CD81 are down-regulated in smoking-related inflammatory response of a macrophage line, RAW264.7....
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