Exosomes from small intestinal epithelium mediate cardiac fibrosis during aging

Abstract excerpt

Senescent cardiac fibroblasts (CFs), which are activated and acquire a profibrotic phenotype, exacerbate age-related interstitial fibrosis and cardiac dysfunction by unclear mechanisms. Traditionally regarded as a central organ involved in regulating aging, the small intestine (SI) communicates with remote organs. However, the mechanisms underlying its role in CFs senescence remain undefined. We aimed to clarify...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cardiovascular Disease and Adiposity
• Share to Extracellular vesicles in disease
• Share to IL-33, ST2, and ILC Pathways