Article
A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors.
Nature communications - 23 Mar 2018
Vigolo Michele, Chambers Melissa G, Willen Laure, Chevalley Dehlia, Maskos Klaus, Lammens Alfred, Tardivel Aubry, Das Dolon, Kowalczyk-Quintas Christine, Schuepbach-Mallepell Sonia, Smulski Cristian R, Eslami Mahya, Rolink Antonius, Hummler Edith, Samy Eileen, Fomekong Nanfack Yves, Mackay Fabienne, Liao Maofu, Hess Henry, Jiang Xuliang, Schneider Pascal
Abstract excerpt
The B cell survival factor (TNFSF13B/BAFF) is often elevated in autoimmune diseases and is targeted in the clinic for the treatment of systemic lupus erythematosus. BAFF contains a loop region designated the flap, which is dispensable for receptor binding. Here we show that the flap of BAFF has two functions. In addition to facilitating the formation of a highly active BAFF 60-mer as shown previously, it also...
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