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Article

Induction of sustained hypercholesterolemia by single adeno-associated virus-mediated gene transfer of mutant hPCSK9.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2015

Roche-Molina Marta, Sanz-Rosa David, Cruz Francisco M, García-Prieto Jaime, López Sergio, Abia Rocío, Muriana Francisco J G, Fuster Valentín, Ibáñez Borja, Bernal Juan A

Abstract excerpt

OBJECTIVES: Patients with mutations in the proprotein convertase subtilisin/kexin type 9 (PCSK9) gene have hypercholesterolemia and are at high risk of adverse cardiovascular events. We aimed to stably express the pathological human D374Y gain-of-function mutant form of PCSK9 (PCSK9(DY)) in adult wild-type mice to generate a hyperlipidemic and proatherogenic animal model, achieved with a single systemic injection...

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Source

Identifiers

PMID: 25341796
DOI: 10.1161/ATVBAHA.114.303617

Genes

PCSK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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