Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant.

Science translational medicine - 2 Jan 2013

Al-Mashhadi Rozh H, Sørensen Charlotte B, Kragh Peter M, Christoffersen Christina, Mortensen Martin B, Tolbod Lars P, Thim Troels, Du Yutao, Li Juan, Liu Ying, Moldt Brian, Schmidt Mette, Vajta Gabor, Larsen Torben, Purup Stig, Bolund Lars, Nielsen Lars B, Callesen Henrik, Falk Erling, Mikkelsen Jacob Giehm, Bentzon Jacob F

Abstract excerpt

Lack of animal models with human-like size and pathology hampers translational research in atherosclerosis. Mouse models are missing central features of human atherosclerosis and are too small for intravascular procedures and imaging. Modeling the disease in minipigs may overcome these limitations, but it has proven difficult to induce rapid atherosclerosis in normal pigs by high-fat feeding alone, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cloning, Organism
Share to Hypercholesterolemia

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hyperlipoproteinemia Type II

Share to Proprotein Convertase 9

Share to Proprotein Convertases

Share to Receptors, LDL

Share to Serine Endopeptidases

Share to Swine, Miniature

Source

Identifiers

PMID: 23283366
DOI: 10.1126/scitranslmed.3004853

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant.PMID 23283366Read ↗

Ossabaw Pigs With a PCSK9 Gain-of-Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies.Semantic proximity Read ↗

Targeted disruption of LDLR causes hypercholesterolemia and atherosclerosis in Yucatan miniature pigs.Semantic proximity Read ↗

CRISPR/Cas9-mediated ApoE-/- and LDLR-/- double gene knockout in pigs elevates serum LDL-C and TC levels.Semantic proximity Read ↗

Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model.Semantic proximity Read ↗

Characterization of a hypertriglyceridemic transgenic miniature pig model expressing human apolipoprotein CIII.Semantic proximity Read ↗

Increased secretion of lipoproteins in transgenic mice expressing human D374Y PCSK9 under physiological genetic control.Semantic proximity Read ↗

Small rodent models of atherosclerosis.Semantic proximity Read ↗

Deficiency of ASGR1 in pigs recapitulates reduced risk factor for cardiovascular disease in humansSemantic proximity Read ↗

Advance of genetically modified pigs in xeno-transplantationSemantic proximity Read ↗

AAV vectors expressing LDLR gain-of-function variants demonstrate increased efficacy in mouse models of familial hypercholesterolemia.Semantic proximity Read ↗

Development of a porcine model of phenylketonuria with a humanized R408W mutation for gene editing.Semantic proximity Read ↗

Engineered Red Blood Cells Carrying PCSK9 Inhibitors Persistently Lower LDL and Prevent ObesitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.