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Article

Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model.

Translational research : the journal of laboratory and clinical medicine - 1 Feb 2018

Hedayat Ahmad F, Park Kyoung-Ha, Kwon Taek-Geun, Woollard John R, Jiang Kai, Carlson Daniel F, Lerman Amir, Lerman Lilach O

Abstract excerpt

Hypercholesterolemia is a major risk factor for atherosclerosis. Remaining challenges in the management of atherosclerosis necessitate development of animal models that mimic human pathophysiology. We characterized a novel mutant pig model with DNA transposition of D374Y gain-of-function (GOF) cDNA of chimp proprotein convertase subtilisin/kexin type-9 (PCSK9), and tested the hypothesis that it would develop...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29175268
DOI: 10.1016/j.trsl.2017.10.007
PMCID: PMC5811343

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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