Article
Normal mitochondrial function in Saccharomyces cerevisiae has become dependent on inefficient splicing.
eLife - 23 Mar 2018
Rudan Marina, Bou Dib Peter, Musa Marina, Kanunnikau Matea, Sobočanec Sandra, Rueda David, Warnecke Tobias, Kriško Anita
Abstract excerpt
Self-splicing introns are mobile elements that have invaded a number of highly conserved genes in prokaryotic and organellar genomes. Here, we show that deletion of these selfish elements from the Saccharomyces cerevisiae mitochondrial genome is stressful to the host. A strain without mitochondrial introns displays hallmarks of the retrograde response, with altered mitochondrial morphology, gene expression and...
Topics
- Base Sequence
- DEAD-box RNA Helicases
- Electron Transport Complex IV
- Gene Expression Regulation, Fungal
- Introns
- Mitochondria
- Mitochondrial Proteins
- Mutation
- Promoter Regions, Genetic
- RNA Splicing
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins