Involvement of C677T MTHFR variant but not A1298C in methotrexate-induced toxicity in acute lymphoblastic leukemia.

doi:10.1177/1078155220951898

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Article

Involvement of C677T MTHFR variant but not A1298C in methotrexate-induced toxicity in acute lymphoblastic leukemia.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners - 1 Sept 2021

Frikha Rim, Jemaa Maha Ben, Frikha Fakher, Turki Ines, Elloumi Moez, Keskes Leila, Kamoun Hassen, Rebai Tarek

Abstract excerpt

BACKGROUND: Methotrexate (MTX) is a key drug in acute lymphoblastic leukemia (ALL) treatment; it inhibits DNA replication by blocking the conversion of 5, 10 Methylenetetrahydrofolate to 5-methylene tetrahydrofolate by methylenetetrahydrofolate reductase (MTHFR). Variants of the Methylenetetrahydrofolate reductase (MTHFR) and MTX related toxicities were largely investigated in several populations, nevertheless,...

Topics

Genotype
Humans
Methotrexate
Methylenetetrahydrofolate Reductase (NADPH2)
Polymorphism, Single Nucleotide
Precursor Cell Lymphoblastic Leukemia-Lymphoma

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Open in PubMed

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PMID: 32865163
DOI: 10.1177/1078155220951898

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