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Article

DNA polymerase ν gene expression influences fludarabine resistance in chronic lymphocytic leukemia independently of p53 status.

Haematologica - 1 Jun 2018

Grgurevic Srdana, Montilla-Perez Patricia, Bradbury Alice, Gilhodes Julia, Queille Sophie, Pelofy Sandrine, Bancaud Aurélien, Filleron Thomas, Ysebaert Loïc, Récher Christian, Laurent Guy, Fournié Jean-Jacques, Cazaux Christophe, Quillet-Mary Anne, Hoffmann Jean-Sébastien

Abstract excerpt

Alteration in the DNA replication, repair or recombination processes is a highly relevant mechanism of genomic instability. Despite genomic aberrations manifested in hematologic malignancies, such a defect as a source of biomarkers has been underexplored. Here, we investigated the prognostic value of expression of 82 genes involved in DNA replication-repair-recombination in a series of 99 patients with chronic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Proportional Hazards Models

Share to Tumor Suppressor Protein p53

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Identifiers

PMID: 29567785
DOI: 10.3324/haematol.2017.174243
PMCID: PMC6058778

Genes

POLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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