Article
DNA polymerase ν gene expression influences fludarabine resistance in chronic lymphocytic leukemia independently of p53 status.
Haematologica - 1 Jun 2018
Grgurevic Srdana, Montilla-Perez Patricia, Bradbury Alice, Gilhodes Julia, Queille Sophie, Pelofy Sandrine, Bancaud Aurélien, Filleron Thomas, Ysebaert Loïc, Récher Christian, Laurent Guy, Fournié Jean-Jacques, Cazaux Christophe, Quillet-Mary Anne, Hoffmann Jean-Sébastien
Abstract excerpt
Alteration in the DNA replication, repair or recombination processes is a highly relevant mechanism of genomic instability. Despite genomic aberrations manifested in hematologic malignancies, such a defect as a source of biomarkers has been underexplored. Here, we investigated the prognostic value of expression of 82 genes involved in DNA replication-repair-recombination in a series of 99 patients with chronic...
Topics
- Animals
- Antineoplastic Combined Chemotherapy Protocols
- Cell Line, Tumor
- DNA-Directed DNA Polymerase
- Disease Progression
- Drug Resistance, Neoplasm
- Gene Expression Profiling
- Gene Expression Regulation, Leukemic