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Article

Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance

17 Feb 2010

Abstract excerpt

Aberrant activation of the translesion DNA synthesis (TLS) pathway has been suggested to play a role in tumorigenesis by promoting genetic mutations. We therefore examined glioma specimens for the expression of specialized DNA polymerases involved in TLS and assessed their prognostic significance. The expression levels of DNA polymerase κ (Pol κ), Pol ι, and Pol η were assessed in 40 primary glioma samples and 10...

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PMID: 20164241
DOI: 10.1093/neuonc/nop074

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