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Article

The JAK2V617F-bearing vascular niche promotes clonal expansion in myeloproliferative neoplasms.

Leukemia - 1 Feb 2018

Zhan H, Lin C H S, Segal Y, Kaushansky K

Abstract excerpt

The acquired kinase mutation JAK2V617F plays a central role in myeloproliferative neoplasms (MPNs). However, the mechanisms responsible for the malignant hematopoietic stem/progenitor cell (HSPC) expansion seen in patients with MPNs are not fully understood, limiting the effectiveness of current treatment. Endothelial cells (ECs) are an essential component of the hematopoietic niche, and they have been shown to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28744010
DOI: 10.1038/leu.2017.233
PMCID: PMC5783797

Genes

CXCL12
MPL
TPO

Provenance

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