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Glucose Levels Alter the Mga Virulence Regulon in the Group A Streptococcus

15 Mar 2018

Abstract excerpt

Many bacterial pathogens coordinately regulate genes encoding important metabolic pathways during disease progression, including the phosphoenolpyruvate (PEP)-phosphotransferase system (PTS) for uptake of carbohydrates. The Gram-positive Group A Streptococcus (GAS) is a pathogen that infects multiple tissues in the human host. The virulence regulator Mga in GAS can be phosphorylated by the PTS, affecting Mga...

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PMID: 29563558
DOI: 10.1038/s41598-018-23366-7

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