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Article

A direct link between carbohydrate utilization and virulence in the major human pathogen group A <i>Streptococcus</i>

30 Jan 2008

Abstract excerpt

Although central to pathogenesis, the molecular mechanisms used by microbes to regulate virulence factor production in specific environments during host-pathogen interaction are poorly defined. Several recent ex vivo and in vivo studies have found that the level of group A Streptococcus (GAS) virulence factor gene transcripts is temporally related to altered expression of genes encoding carbohydrate utilization...

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PMID: 18230719
DOI: 10.1073/pnas.0711767105

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