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Article

PTS phosphorylation of Mga modulates regulon expression and virulence in the group A streptococcus

8 May 2013

Abstract excerpt

The ability of a bacterial pathogen to monitor available carbon sources in host tissues provides a clear fitness advantage. In the group A streptococcus (GAS), the virulence regulator Mga contains homology to phosphotransferase system (PTS) regulatory domains (PRDs) found in sugar operon regulators. Here we show that Mga was phosphorylated in vitro by the PTS components EI/HPr at conserved PRD histidines. A ΔptsI...

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PMID: 23651410
DOI: 10.1111/mmi.12250

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