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Article

Genetic polymorphisms of IFNL3 are associated with risk of immune checkpoint inhibitor-related pneumonitis in lung cancer patients.

Cytokine - 1 Oct 2025

Peng Shengzu, Duan Zhihui, Zhang Kai, Lu Tao, Zheng Guanghua

Abstract excerpt

BACKGROUND: Checkpoint inhibitor-related pneumonitis (CIP) is the most common fatal adverse reaction among lung cancer patients received immune checkpoint inhibitors (ICIs) therapy. IFN-λ3 has anti-tumor and immunomodulatory effects in lung cancer; however, little is known about the IFNL3 polymorphisms in CIP susceptible population. METHODS: Five candidate IFNL3 polymorphisms were genotyped in 102 CIP and 626...

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Identifiers

PMID: 40743639
DOI: 10.1016/j.cyto.2025.157002

Genes

IFNL3

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