A functional IFN-λ4-generating DNA polymorphism could protect older asthmatic women from aeroallergen sensitization and associate with clinical features of asthma.

doi:10.1038/s41598-017-10467-y

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A functional IFN-λ4-generating DNA polymorphism could protect older asthmatic women from aeroallergen sensitization and associate with clinical features of asthma.

Scientific reports - 5 Sept 2017

Chinnaswamy Sreedhar, Wardzynska Aleksandra, Pawelczyk Malgorzata, Makowska Joanna, Skaaby Tea, Mercader Josep M, Ahluwalia Tarunveer S, Grarup Niels, Guindo-Martinez Marta, Bisgaard Hans, Torrents David, Linneberg Allan, Bønnelykke Klaus, Kowalski Marek L

Abstract excerpt

Lambda interferons (IFNLs) have immunomodulatory functions at epithelial barrier surfaces. IFN-λ4, a recent member of this family is expressed only in a subset of the population due to a frameshift-causing DNA polymorphism rs368234815. We examined the association of this polymorphism with atopy (aeroallergen sensitization) and asthma in a Polish hospital-based case-control cohort comprising of well-characterized...

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PMID: 28874741
DOI: 10.1038/s41598-017-10467-y
PMCID: PMC5585370

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