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Article

JAK signaling globally counteracts heterochromatic gene silencing.

Nature genetics - 1 Sept 2006

Shi Song, Calhoun Healani C, Xia Fan, Li Jinghong, Le Long, Li Willis X

Abstract excerpt

The JAK/STAT pathway has pleiotropic roles in animal development, and its aberrant activation is implicated in multiple human cancers. JAK/STAT signaling effects have been attributed largely to direct transcriptional regulation by STAT of specific target genes that promote tumor cell proliferation or survival. We show here in a Drosophila melanogaster hematopoietic tumor model, however, that JAK overactivation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16892059
DOI: 10.1038/ng1860
PMCID: PMC3092431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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