Article
Adjuvant Treatment for POLE Proofreading Domain-Mutant Cancers: Sensitivity to Radiotherapy, Chemotherapy, and Nucleoside Analogues.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2018
Van Gool Inge C, Rayner Emily, Osse Elisabeth M, Nout Remi A, Creutzberg Carien L, Tomlinson Ian P M, Church David N, Smit Vincent T H B M, de Wind Niels, Bosse Tjalling, Drost Mark
Abstract excerpt
Purpose: Pathogenic POLE proofreading domain mutations are found in many malignancies where they are associated with ultramutation and favorable prognosis. The extent to which this prognosis depends on their sensitivity to adjuvant treatment is unknown, as is the optimal therapy for advanced-staged or recurrent POLE-mutant cancers.Experimental Design: We examined the recurrence-free survival of women with...
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