Article
A PoleP286R mouse model of endometrial cancer recapitulates high mutational burden and immunotherapy response.
JCI insight - 23 Jul 2020
Li Hao-Dong, Lu Changzheng, Zhang He, Hu Qing, Zhang Junqiu, Cuevas Ileana C, Sahoo Subhransu S, Aguilar Mitzi, Maurais Elizabeth G, Zhang Shanrong, Wang Xiaojing, Akbay Esra A, Li Guo-Min, Li Bo, Koduru Prasad, Ly Peter, Fu Yang-Xin, Castrillon Diego H
Abstract excerpt
Cancer is instigated by mutator phenotypes, including deficient mismatch repair and p53-associated chromosomal instability. More recently, a distinct class of cancers was identified with unusually high mutational loads due to heterozygous amino acid substitutions (most commonly P286R) in the proofreading domain of DNA polymerase ε, the leading strand replicase encoded by POLE. Immunotherapy has revolutionized...
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