Article
An optically controlled probe identifies lipid-gating fenestrations within the TRPC3 channel.
Nature chemical biology - 1 Apr 2018
Lichtenegger Michaela, Tiapko Oleksandra, Svobodova Barbora, Stockner Thomas, Glasnov Toma N, Schreibmayer Wolfgang, Platzer Dieter, de la Cruz Gema Guedes, Krenn Sarah, Schober Romana, Shrestha Niroj, Schindl Rainer, Romanin Christoph, Groschner Klaus
Abstract excerpt
Transient receptor potential canonical (TRPC) channels TRPC3, TRPC6 and TRPC7 are able to sense the lipid messenger diacylglycerol (DAG). The DAG-sensing and lipid-gating processes in these ion channels are still unknown. To gain insights into the lipid-sensing principle, we generated a DAG photoswitch, OptoDArG, that enabled efficient control of TRPC3 by light. A structure-guided mutagenesis screen of the TRPC3...
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