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Article

The curious case of Gαs gain-of-function in neoplasia.

BMC cancer - 15 Mar 2018

Innamorati Giulio, Wilkie Thomas M, Kantheti Havish S, Valenti Maria Teresa, Dalle Carbonare Luca, Giacomello Luca, Parenti Marco, Melisi Davide, Bassi Claudio

Abstract excerpt

BACKGROUND: Mutations activating the α subunit of heterotrimeric Gs protein are associated with a number of highly specific pathological molecular phenotypes. One of the best characterized is the McCune Albright syndrome. The disease presents with an increased incidence of neoplasias in specific tissues. MAIN BODY: A similar repertoire of neoplasms can develop whether mutations occur spontaneously in somatic...

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Share to Bone Tumor Diagnosis and Treatments
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Syndromes and Imprinting

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Identifiers

PMID: 29544460
DOI: 10.1186/s12885-018-4133-z
PMCID: PMC5856294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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