Article
Minireview: GNAS: normal and abnormal functions.
Endocrinology - 1 Dec 2004
Weinstein Lee S, Liu Jie, Sakamoto Akio, Xie Tao, Chen Min
Abstract excerpt
GNAS is a complex imprinted gene that uses multiple promoters to generate several gene products, including the G protein alpha-subunit (G(s)alpha) that couples seven-transmembrane receptors to the cAMP-generating enzyme adenylyl cyclase. Somatic activating G(s)alpha mutations, which alter key residues required for the GTPase turn-off reaction, are present in various endocrine tumors and fibrous dysplasia of bone,...
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