Article
McCune Albright syndrome is a genetic predisposition to intraductal papillary and mucinous neoplasms of the pancreas associated pancreatic cancer in relation with GNAS somatic mutation - a case report.
Medicine - 1 Dec 2019
Gaujoux Sébastien, Pasmant Eric, Silve Caroline, Mehsen-Cetre Nadia, Coriat Romain, Rouquette Alexandre, Douset Bertrand, Prat Frédéric, Leroy Karen
Abstract excerpt
RATIONALE: Intraductal papillary and mucinous neoplasms of the pancreas (IPMN) are preneoplastic lesions diagnosed with an increasing incidence. Recently, several groups have described, in up to 70% of IPMN, activating mutations of the G-protein alpha stimulatory sub-unit (Gsα subunit) gene (GNAS). GNAS-activating somatic, post-zygotic, mutations are also associated with McCune-Albright syndrome (MCAS)...
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