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Article

Impact of Mitochondrial Permeability on Endothelial Cell Immunogenicity in Transplantation.

Transplantation - 1 Jun 2018

Tran Danh T, Esckilsen Scott, Mulligan Jennifer, Mehrotra Shikhar, Atkinson Carl, Nadig Satish N

Abstract excerpt

BACKGROUND: Microvascular endothelial cells (ECs) are central to an allograft's immunogenicity. Cold ischemia and reperfusion injury associated with static cold storage and warm reperfusion activates ECs and increases the immunogenicity of the allograft. After reperfusion, mitochondrial permeability transition pore (mPTP) opening contributes to mitochondrial dysfunction in the allograft, which correlates to...

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Source

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Identifiers

PMID: 29538260
DOI: 10.1097/TP.0000000000002163
PMCID: PMC5962417

Genes

CCL2
TAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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