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Mitochondrial DNA levels in perfusate and bile during ex vivo normothermic machine correspond with donor liver quality

24 Feb 2024

Abstract excerpt

normothermic machine perfusion (NMP) preserves donor organs and permits real-time assessment of allograft health, but the most effective indicators of graft viability are uncertain. Mitochondrial DNA (mtDNA), released consequent to traumatic cell injury and death, including the ischemia-reperfusion injury inherent in transplantation, may meet the need for a biomarker in this context. We describe a real time...

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PMID: 38463874
DOI: 10.1016/j.heliyon.2024.e27122

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