Article
Predicted effect of circadian clock modulation of NHE3 of a proximal tubule cell on sodium transport.
American journal of physiology. Renal physiology - 1 Sept 2018
Wei Ning, Gumz Michelle L, Layton Anita T
Abstract excerpt
Major renal functions such as renal blood flow, glomerular filtration rate, and urinary excretion are known to exhibit circadian oscillations. However, the underlying mechanisms that govern these variations have yet to be fully elucidated. To better understand the impact of the circadian clock on renal solute and water transport, we have developed a computational model of the renal circadian clock and coupled...
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