Article
Human organic anion transporter 3 gene is regulated constitutively and inducibly via a cAMP-response element.
The Journal of pharmacology and experimental therapeutics - 1 Oct 2006
Ogasawara Ken, Terada Tomohiro, Asaka Jun-Ichi, Katsura Toshiya, Inui Ken-Ichi
Abstract excerpt
Human organic anion transporter (OAT) 3 (SLC22A8) is localized to the basolateral membranes of renal tubular epithelial cells and plays a critical role in the excretion of anionic compounds. We previously reported that interindividual variation in the OAT3 mRNA level corresponded to interindividual differences in the rate of renal excretion of cefazolin. However, there is little information available on the...
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