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Article

Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension.

Physiological genomics - 1 Oct 2015

Li Xiao C, Shull Gary E, Miguel-Qin Elisa, Zhuo Jia L

Abstract excerpt

The renal mechanisms responsible for angiotensin II (ANG II)-induced hypertension remain incompletely understood. The present study tested the hypothesis that the Na(+)/H(+) exchanger 3 (NHE3) is required for ANG II-induced hypertension in mice. Five groups of wild-type (Nhe3(+/+)) and Nhe3(-/-) mice were treated with vehicle or high pressor doses of ANG II (1.5 mg/kg/day ip, via minipump for 2 wk, or 10 pmol/min...

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Source

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Identifiers

PMID: 26242933
DOI: 10.1152/physiolgenomics.00056.2015
PMCID: PMC4593829

Genes

ANG
AQP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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