Article
Trichostatin A inhibits the activation of Hepatic stellate cells by Increasing C/EBP-α Acetylation in vivo and in vitro.
Scientific reports - 13 Mar 2018
Ding Di, Chen Lin-Lin, Zhai Ying-Zhen, Hou Chen-Jian, Tao Li-Li, Lu Shu-Han, Wu Jian, Liu Xiu-Ping
Abstract excerpt
Reversal of activated hepatic stellate cells (HSCs) to a quiescent state and apoptosis of activated HSCs are key elements in the reversion of hepatic fibrosis. CCAAT/enhancer binding protein α (C/EBP-α) has been shown to inhibit HSC activation and promote its apoptosis. This study aims to investigate how C/EBP-α acetylation affects the fate of activated HSCs. Effects of a histone deacetylation inhibitor...
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