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Article

TGF-β1 promotes cell barrier function upon maturation of corneal endothelial cells.

Scientific reports - 13 Mar 2018

Beaulieu Leclerc Véronique, Roy Olivier, Santerre Kim, Proulx Stéphanie

Abstract excerpt

Human corneal endothelial cells (HCECs) easily become fibroblastic-like when cultured, rendering them unsuitable for tissue engineering of the cornea. Transforming growth factor β (TGF-β) could be a key factor in this phenomenon; however, TGF-β is also known to maintain the endothelium in a quiescent state in vivo. This work aimed to compare the effects of TGF-β1 on the phenotype of HCECs during the proliferation...

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Identifiers

PMID: 29535350
DOI: 10.1038/s41598-018-22821-9
PMCID: PMC5849742

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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