Article
Inhibition of TGF-β signaling enables human corneal endothelial cell expansion in vitro for use in regenerative medicine.
PloS one - 1 Jan 2013
Okumura Naoki, Kay EunDuck P, Nakahara Makiko, Hamuro Junji, Kinoshita Shigeru, Koizumi Noriko
Abstract excerpt
Corneal endothelial dysfunctions occurring in patients with Fuchs' endothelial corneal dystrophy, pseudoexfoliation syndrome, corneal endotheliitis, and surgically induced corneal endothelial damage cause blindness due to the loss of endothelial function that maintains corneal transparency. Transplantation of cultivated corneal endothelial cells (CECs) has been researched to repair endothelial dysfunction in...
Topics
- Animals
- Bone Morphogenetic Protein 7
- Cell Membrane
- Cells, Cultured
- Collagen Type I
- Cornea
- Endothelial Cells
- Endothelium, Corneal
- Fibroblasts
- Humans
- Phenotype