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Article

Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs

1 Feb 2021

Abstract excerpt

The conjunctival epithelium, which covers the sclera (the white of the eye) and lines the inside of the eyelids, is essential for mucin secretion and the establishment of a healthy tear film. Here, we describe human conjunctival development in a self-formed ectodermal autonomous multi-zone (SEAM) of cells that were derived from human-induced pluripotent stem cells (hiPSCs) and mimic whole-eye development. Our...

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PMID: 33535050
DOI: 10.1016/j.celrep.2021.108715

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