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Article

IGFBP4 suppresses EndMT and preserves rabbit corneal endothelial cell phenotypes by inhibiting the Wnt2/β-catenin signaling pathway.

Experimental eye research - 1 Sept 2026

Ke Hongqin, Cao Qian, Li Yong, Long Junjun, Tian Ermiao, Li Lan, Liu Hai

Abstract excerpt

Endothelial-mesenchymal transition (EndMT) represents a major limiting factor in the in vitro expansion of corneal endothelial cells (CECs). This study aims to identify the key genes and signaling pathways driving EndMT in rabbit CECs (RCECs) and to explore targeted interventions to preserve cellular phenotype, ultimately improving in vitro culture protocols. During serial passaging, primary RCECs underwent...

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Source

Identifiers

PMID: 42248388
DOI: 10.1016/j.exer.2026.111107

Genes

IGFBP4
WNT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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