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Article

Telomerase Immortalization of Human Corneal Endothelial Cells Yields Functional Hexagonal Monolayers

21 Dec 2012

Abstract excerpt

Human corneal endothelial cells (HCEnCs) form a monolayer of hexagonal cells whose main function is to maintain corneal clarity by regulating corneal hydration. HCEnCs are derived from neural crest and are arrested in the post-mitotic state. Thus cell loss due to aging or corneal endothelial disorders leads to corneal edema and blindness-the leading indication for corneal transplantation. Here we show the...

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PMID: 23284695
DOI: 10.1371/journal.pone.0051427

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